Linaclotide enim gastrointestinal perturbationes 851199-59-2
Product Detail
| Nomen | Linaclotide |
| Cas numerum | 851199-59-2 |
| MOLECULA | C59h79no21s6 |
| Pondus | 1526,74 |
Synonyma
Linacllotide, Linaclotide; Linaelotideacetate; Linaelotide; CY-XIV, LLLOLOTIDE, Argessin, L-Tyrosine, L-cysteinyl, L-cysteyll-l-α-g Glutamyl -L-cysteinyl-l-cysteinyl, l-asparaginyl-l-prolyll-l-alanyl, l-cysteinyl-l-l-treonylglycyl-l-cysteinyl, cyclic (I → VI, cysteinyl-, cyclic (I → VI), (II → (I → VI), (II → (I →), (II (I (I →) -Tris (I (I V) -Tris (Disulfide),
Descriptio
Linaclotide, a synthetica peptide compages continet XIV amino acida, est ad endogenous guanosine peptide familiam et est solum FDA-probatus GC-C (Guanylate pro Cyclase-C) Agonist in constipation (IBS-C) et Chronic in Constipation (CIC) in adultis.
Eget proprietatibus
Linaclotide est albus ad off-album amorphous pulveris; Leviter solutum in aqua et aqueum sodium chloride solutio (0.9%).
Quid est operatur
Linaclotide est Guanylate Cyclase-C receptor agonist (GCCA) cum utrumque Visceral analgesic et endocrinarum actum. Tum Linaclotide et active metabolite potest ligare ad Guanylate Cyclase-C (GC) receptor in luminal superficies parva intestinorum epithelium. In animal exempla, Linaclotide reduces visceralis dolor et crescit gastrointestinal transit per activation of Gc-C, et in hominibus, in medicamento etiam crescit colonic transit. Et propter GC-c activation est auctus intracellular et extracellular CGMP (Cyclic Guanosine monophosphate) concentratione. Extracellular CGMP potest reducere operatio doloris nervi fibris et redigendum viscerum dolor in exemplum animalibus. Intracellular CGMP potest crescere secretionem chloride et bicarbonate in parva intestinum activum CFTR (cystic fibrosmembrane conductance regulator), quae eventually ducit ad augmentum parvum intestinorum fluidum secretio et celeritas parvum intestinorum fluidum secretio et celeritate parvis transit.
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