Vancomycinum est antibioticum glycopeptidicum ad antibacterialem usum.
Detalia Producti
| Nomen | Vancomycinum |
| Numerus CAS | 1404-90-6 |
| Formula molecularis | C66H75Cl2N9O24 |
| Pondus moleculare | 1449.25 |
| Numerus EINECS | 215-772-6 |
| Densitas | 1.2882 (aestimatio approximata) |
| Index refractionis | 1.7350 (aestimatio) |
| Conditiones repositionis | Sigillo sicco, 2-8°C, obsignatum |
Synonyma
Vancomycinum (basis et/vel sales non specificati); VANCOMYCINUM; Vancomycinum basis; (3S, 6R, 7R, 22R, 23S, 26S, 36R, 38aR)-3-(2-amino-2-oxoethyl)-44-[[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranosyl]oxy]-10,19-dichloro-2,3,4,5,6,7,23,24,25,26,36,37,38,38a-tetradecahydro-7. 22,28,30,32-pentahydroxy-6-[[(2R)-4-methylyl-2-(methylamino)-1-oxopentyl]amino]-2,5,24,38,39-pentaoxo-22H-8,11:18,21-Dietheno-23,36-(iminomethano)-13,16:31,35-dimetheno-1H,16H-[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosinum-26-carboxylicum acidum.
Descriptio
Vancomycinum est antibioticum glycopeptidicum. Eius mechanismus actionis est alanylalanino, quod in extremo polyterminali peptidi praecursoris parietis cellularis bacterialis sensibilis est, magna affinitate se ligare, synthesim peptidoglycani macromolecularis, quod parietem cellularem bacterialem constituit, inhibens, quod ad destructionem parietis cellularis ducit, quae bacteria necat. Vancomycinum efficax est ad infectiones graves a bacteriis Gram-positivis causatas, praesertim eas quae a Staphylococco aureo methicillino resistente, Staphylococco epidermidis, et Enterococco, qui aliis antibioticis resistunt vel efficaciam parvam habent, causantur.
Indicia
Limitatur ad infectiones systemicas a Staphylococco aureo methicillino resistente (MRSA) causatas, necnon ad infectiones intestinales et infectiones systemicas a Clostridio difficile causatas; aegroti penicillino allergici penicillina vel cephalosporina uti non possunt; in aegrotis infectione staphylococcica gravi cum, vel in iis qui infectione staphylococcica gravi cum non responderunt antibioticis supradictis, vancomycinum adhiberi potest. Hoc productum etiam adhibetur ad curationem endocarditidis Enterococci et endocarditidis Corynebacterii (diphtheriae similis) in hominibus penicillino allergicis. Curatio infectionum shunt arteriovenosarum a staphylococco inductarum in aegrotis haemodialysis allergicis penicillino et non allergicis penicillino.
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