Daptomycinum 103060-53-3 ad Morbos Infectiosos
Detalia Producti
| Nomen | Daptomycinum |
| Numerus CAS | 103060-53-3 |
| Formula molecularis | C72H101N17O26 |
| Pondus moleculare | 1620.67 |
| Numerus EINECS | 600-389-2 |
| Punctum fusionis | 202-204°C |
| Punctum ebullitionis | 2078.2±65.0°C (Praedictum) |
| Densitas | 1.45±0.1 g/cm³ (Praedictum) |
| Punctum inflammationis | 87℃ |
| Conditiones repositionis | Sigillo sicco obsignatum, in armario frigorifico sub -20°C conservandum. |
| Solubilitas | Methanolum: solubile 5mg/mL |
| Coefficiens aciditatis | (pKa) 4.00±0.10 (Praedictum) |
| Forma | pulvis |
| Color | incolor ad pallide flavum |
Synonyma
N-[N-(1-Oxodecyl)-L-Trp-D-Asn-L-Asp-]-cyclo[L-Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-methyl-L-Glu-]-4-(2-aminophenyl)-4-oxo-L-Abu-]; N-[N-Decanoyl-L-Trp-D-Asn-L-Asp-]-cyclo[Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-methyl-L-Glu-]-3-(2-aminobenzoyl)-L-Ala-]; N-(1-Oxod *ecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithinyl-L-α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R)-3-methyl-L-α-glutamyl-α,2-diamino-γ-oxo-benzenebutanoica acidi(13-4)lactonum; DAPTOMYCINUM; Dapcinum; Daptomycinum, >=99%; Daptomycinum Solutio Praeparata; Daptomycinum (LY146032)*
Descriptio
Antibioticum daptomycinum est antibioticum lipopeptidicum cyclicum novae structurae ex liquore fermentationis Streptomycis (S. reseospori) extractae, quae biosynthesis peptidoglycani parietis cellularis bacterialis impedit perturbando translationem aminoacidorum in membrana cellulari. Proprietates membranae cytoplasmaticae mutantes functionem membranae bacterialis multis modis perturbare et bacteria Gram-positiva celeriter necare possunt. Praeter facultatem agendi in pleraque bacteria Gram-positiva clinicē pertinentia, daptomycinum maioris momenti est pro stirpibus isolatis quae resistentiam methicillino, vancomycino, et linezolido in vitro demonstraverunt. Actionem potentem habet, et haec proprietas implicationes clinicas gravissimas habet pro aegris gravē infectis. Pneumonia eosinophilica est morbus rarus et gravissimus, cuius symptomata includunt febrem, tussis, dyspnoeam, et difficultatem spirandi.
Effectus Antibacterialis
Daptomycinum bonam actionem bacteriostaticam contra varia bacteria antibioticis resistentia habet, ut MIC = 0.06-0.5 μg/ml pro Staphylococco aureo methicillino resistente (MRSA), et Staphylococco aureo methicillino resistente (MRSA). MIC = 0.0625～1μg/ml pro bacteriis, MIC = 0.12～0.5μg/ml pro Staphylococco epidermidis oxacillino resistente, MIC = 2.5μg/ml pro enterococco antibioticis aminoglycosidicis valde resistente, MIC = 2.5μg/ml pro GmrBIa. MIC Enterococci est 0.5～1μg/ml, et MIC Enterococci antibioticis glycopeptidicis resistentis est 1～2μg/ml.
