Daptomycin 103060-53-3 de morbis infectivis
Product Detail
| Nomen | Daptomycin |
| CAS numerus | 103060-53-3 |
| Formulae hypotheticae | C72H101N17O26 |
| M. pondus | 1620.67 |
| EINECS Number | 600-389-2 |
| Liquescens punctum | 202-204°C |
| Ferveret | 2078.2±65.0 °C (Predicta) |
| Density | 1.45±0.1 g/cm3(praedicta) |
| Mico punctum | 87℃ |
| Repono conditionibus | Sub -20°C . signatus in sicco, Store in freezer |
| Solubilitas | Methanolum: soluble5mg/mL |
| Acidum coefficiens | (pKa) 4.00±0.10 (Praedicta) |
| Forma | pulvis |
| Color | hyalina deficere flavo |
Synonyma
N-[N-(1-Oxodecyl)-L-Trp-D-Asn-L-Asp-]-cyclo[L-Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp- Gly-D-Ser-[(3R)-3-methyl-L-Glu-]-4-(2-aminophenyl)-4-oxo-L-Abu-];N-[N-Decanoyl-L-Trp- D-Asn-L-Asp-]-cyclus [Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-methyl-L- Glu-]-3-(2-aminobenzoyl)-L-Ala-];N(1-Oxodecyl)-L. α-aspartyl-D-alanyl-L- α-aspartylglycyl-D-seryl(3R) -3-methyl-L-a glutamyl-α, 2-diamino-γ-oxo-benzenebutanoicacid(13-4) lactone; DAPTOMYCINE;
Descriptio
Daptomycinum antibioticum est cyclicum lipopeptidum antibioticum cum nova structura e fermenti ius Streptomycis (S. reseosporo) extracta, quae biosynthesin parietis cellulae peptidoglycani bacterialis impedit perturbando amino acida in membranam cellulam transvehendam.Commutans proprietates membranae cytoplasmicae functionis bacteriales multipliciter perturbare potest et celeriter bacteria gram-positivam necant.Praeter eius facultatem agendi in bacteria maxime amet spectantia Gram-positiva, daptomycin potior est pro modis solitariis quae resistentiam methicillino, vancomycin, et linezolid in vitro ostenderunt.Potens activitatem habet, et haec proprietas magni ponderis effectus clinicos habet pro aegros infectis critico aegrotantibus.Peripleumonicum eosinophilicum rarus et gravissimus morbus est cum symptomata febris, tussis, suspirium, difficultas spirandi.
Effectus antibacterial
Daptomycin bonam bacteriostaticam actionem contra varias bacteria antibiotico-resistentes habet, ut MIC=0.06-0.5 μg/ml pro methicillino-resistenti Staphylococcus aureus (MRSA), et methicillin-repugnans Staphylococcus aureus (MRSA).MIC=0.0625～1μg/ml pro bacteria, MIC=0.12～0.5μg/ml pro epidermidis oxacillino-obsistenti Staphylococcus, MIC=2.5μg/ml pro enterococco antibiotico aminoglycoside valde repugnante, MIC=2.5μg/ml pro GmrBIa -The MIC of Enterococci est 0.5～1μg/ml, et MIC Enterococci resistens glycopeptidi antibioticorum est 1～2μg/ml.
