Sildenafil Citras ad Impotentiam Curandam 171599-83-0
Detalia Producti
| Nomen | Sildenafilum Citras |
| Numerus CAS | 171599-83-0 |
| Formula molecularis | C28H38N6O11S |
| Pondus moleculare | 666.70 |
| Numerus EINECS | 200-659-6 |
| Merck | 14,8489 |
| Densitas | 1.445g/cm³ |
| Conditio repositionis | 2-8°C |
| Forma | Pulvis |
| Color | Albus |
| Solubilitas in aqua | DMSO: >20mg/mL |
Synonyma
Viagra, Sildenafili citras; 1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazincitrassal; 5-[2-Ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[5,4-e]pyrimidin-7-onecitrassal; 1-[[3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazinum, 2-hydroxy-1,2,3-propanetricarboxylatum; Sildenafilcitras (100 mg); Sildenafilcitras, >=99%; Sildenafilcitras, Copia Professionalis; 5-[2-Ethoxy-5-[(4-methyl-piperazin-1-yl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-onecitras.
Effectus Pharmacologicus
Actio Pharmacologica
Sildenafili citras est inhibitor selectivus 5-phosphodiesterasis qui vasodilatationem pulmonalem a oxido nitrico dependentem et a guanosino monophosphato cyclico mediatam auget, per inhibitionem dissolutionis guanosini monophosphati cyclici. Praeter expansionem directam vasorum sanguineorum pulmonalium, etiam remodellationem vascularem impedire vel invertere potest.
Proprietates et Applicationes Medicinales
Sildenafili citras, nomine commerciali Viagra, vulgo Viagra appellatus, est inhibitor phosphodiesterasis typi 5 (PDE5) cyclici guanosini monophosphatis (cGMP) specificus, qui erectionem post administrationem oralem augere potest. Sildenafili citras effectum oxidi nitrici (NO) augere potest inhibendo phosphodiesterasis typi 5 quae guanosini monophosphatis cyclici (cGMP) in corpore cavernoso decomponit. Gradum cGMP in corpore cavernoso auget, musculos leves in corpore cavernoso relaxat, influxum sanguinis auget, tempus erectionis penis prolongat et firmitatem auget. Pro aegris impotentiae cum dysfunctione erectili. Adulti 50 mg per os sumunt, usque ad semel in die, et pro re nata circiter unam horam ante coitum utuntur. Quantitas maxima est 0.1g singulis vicibus.
Studia in vivo
In canibus anesthetizatis, Sildenafil citras functionem erectilem penilem sub stimulatione nervi pelvici per mensurationem pressionis intracavernosae auget. Sildenafil citras relaxationem carbamoylcholino stimulatam impeditam insigniter invertit et formationem superoxidi in textu cavernoso cuniculorum hypercholesterolemicorum inhibuit. In muribus Sprague-Dawley, Sildenafil functionem erectilem modo tempore et dosi dependente emendat, maxima recuperatione die 28 dosi 20 mg/kg per diem occurrente. In muribus Sprague-Dawley, administratio Sildenafil conservationem rationis collageni musculi levis et conservationem expressionis CD31 et eNOS effecit. In muribus Sprague-Dawley, Sildenafil indicem apoptoticum significanter minuit et phosphorylationem akt et eNOS comparatus cum grege testigo auxit.
