Pregabalin ad curatio periphericis neuralgia et adjuvant curatio de localized partialium invasiones

Pharmacological effectus
Pregabalin habet bonum therapeutica effectus in comitialibus. Studiis in variis animalis epileptici masculorum exempla ostensum est quod pregabalin potest significantly ne epileptici caducis, et activae dose est 3-10 temporibus inferioribus quam Gabapentin. Studies have found that pregabalin can reduce the sensory and motor spinal cord reflexes of rat pinch-toe stimulation, reduce the related behaviors of neuropathic animal pain models with diabetes, peripheral nerve injury or chemotherapy, and inhibit or reduce the pain-related pain caused by spinal stimuli. mores. Animal studiis invenerunt quod pregabalin ut commoda respectu cum opioids. Pregabalin providet novum optionem ad orci curatio neuropathic dolor.

Mechanism
Pregabalin ut redigendum calcium, dependens release de aliquo neurotransmitters per modulating calcium channel munus. Although pregabalin is a structural derivative of the inhibitory neurotransmitter γ-aminobutyric acid (GABA), it does not directly bind to GABAA, GABAB, or benzodiazepine receptors and does not increase GABAA in cultured neurons Reaction, does not change the concentration of GABA in the brain of rats, and has no acute effect on GABA uptake or Degradation. Tamen, studium invenit quod longius nuditate excultus neurons ad pregabalin augeri densitate Gaba Transporters et rate of eget Gaba onerariam. Pregabalin does not block sodium channels, has no activity on opioid receptors, does not alter cyclooxygenase activity, has no activity on dopamine and serotonin receptors, and does not inhibit the reactivation of dopamine, serotonin, or norepinephrine. Ingest.

Medicina interactiones
I. Non metabolized a Cytochrome P450 ratio ergo raro interacts cum aliis medicamento. Non afficit pharmacokinetics de Antiepileptic medicamentis (ut sodium valproate, Phenytoin, Lamotrigine, Carbazepine, Phenobarbital, Topiramate), oralis contraceptives, oralis, oralis, oralis, oralis, oralis, et insulin.
II. Cum hoc productum adhibetur una cum oxycodone, eius recognitionem munus erit reduci et motor munus damnum erit auctus.
III. Eam habet EXPECTATIO effectus cum Lorazepam et Ethanol.